When I play Rust, I spend about 80% of my time running. After several hours of juking arrows and climbing mountains my WASD hand gets wicked cramps holding the shift key.
Here are some quick key bindings that you can use to save your hands as well as other useful combat key bindings to use on the field.
Rust Key Bindings
Press Q to auto-run, press Shift or W to cancel.
bind q forward;sprint
Press Z to permanently crouch and auto-attack, press Left Click and Control to cancel.
bind z attack;duck
Hold Z to crouch and auto-attack (only while pressed.)
bind z +attack;+duck
Press C to permanently crouch, press Control to cancel.
bind c duck